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Postvaccination testing for anti-HBs and HBsAg should be performed at age 9--15 months because of the infant's on-going exposure to HBV.
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Trimethoprim: May decrease the excretion of LamiVUDine.
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Tell HIV patient that drug doesn't cure virus or prevent its transmission and that opportunistic infections may occur.
The impact of inducers of drug metabolizing enzymes, such as phenytoin and phenobarbital, on UGT1A1 is unknown.
The development of mutant HBV in the lamivudine groups was associated with increases in both alanine aminotransferase and HBV DNA levels over the lowest values before the mutations developed, although at 52 weeks the levels were still lower than pretreatment values.
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Antiviral Therapy of HBV- and HCV-induced Liver Cirrhosis.
After oral administration of Lamivudine once daily to HBV-infected adults, the AUC and C max increased in proportion to dose over the range from 5 mg to 600 mg once daily.
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HIV-1 resistance may emerge in chronic hepatitis B patients with unrecognized or untreated HIV-1 infection because the lamivudine dosage in lamivudine tablets is subtherapeutic and monotherapy is inappropriate for the treatment of HIV-1 infection.
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Evaluation of therapies for hepatitis B virus in the HBV transgenic SCID mouse model.
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The newly listed contraindicated regimens are a three-NRTI regimen with abacavir, tenofovir, and lamivudine (because of early virologic nonresponse); a three-NRTI regimen with didanosine, tenofovir, and lamivudine (because of a high rate of virologic failure); the combination of didanosine and stavudine (because of a high incidence of toxicities, including several deaths); the combination of atazanavir and indinavir (both of which can cause high-grade hyperbilirubinemia and jaundice); and emtricitabine plus lamivudine as a two-NRTI backbone (since both drugs have similar resistance profiles and minimal additive antiviral activity).
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Virologic Monitoring of Hepatitis B Virus Therapy in Clinical Trials and Practice: Recommendations for a Standardized Approach.
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Telbivudine treatment should be discontinued if either peripheral neuropathy or myopathy is diagnosed.
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Lamivudine therapy for prevention of immunosuppressive-induced hepatitis B virus reactivation in hepatitis B surface antigen carriers.
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Percentage of people affected-Women are affected by major depression twice as much as men.
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In clinical practice, monitoring of ALT and HBV DNA levels during lamivudine treatment may aid in treatment decisions if emergence of viral mutants is suspected.
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It is only approved for use in combination with other medications for the treatment of HIV.
HBV DNA levels at month 3 of treatment.
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Treatment with EPZICOM should be suspended in any patient who develops clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity (which may include hepatomegaly and steatosis even in the absence of marked transaminase elevations).
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RD, et al, HIV Research Network.
In each treatment group, 85 percent of the patients were male and 98 percent were Asian.
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Reproduction studies with lamivudine and zidovudine have been performed in animals (see Lamivudine and Zidovudine sections below).
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Treatment and prevention of chronic viral hepatitis.
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The efficacy of cryotherapy is 60%--80%.
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In vitro resistance profile of TMC278, a next-generation NNRTI; evidence of a higher genetic barrier and a more robust resistance profile than first generation NNRTIs.
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Such patients will have a 5-year survival of 50% to 75%.
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