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Efavirenz: Assessment of adverse reactions is based on three pediatric clinical trials in 182 HIV-1 infected pediatric subjects 3 months to 21 years of age, who received efavirenz in combination with other antiretroviral agents for a median of 123 weeks.
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Proven or suspected acute hepatitis within 30 days prior to study entry (this excludes liver inflammation related to acute HIV infection).
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Universal Antiretroviral Therapy for HIV Infection: Should US Treatment Guidelines Be Applied to Resource-Limited Settings?
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Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial.
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Unless otherwise noted, frequency of adverse events is as reported in adults receiving combination antiretroviral therapy.
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En 2006, la FDA aprobó la combinación de tenofovir, emtricitabina y efavirenz en una misma tableta, lo que facilita la adherencia de los pacientes al tratamiento antirretroviral.
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Patients who take ergot alkaloids, midazolam, astemizole, cisapride or triazolam should avoid Efavir.
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Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks.
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As a rule of thumb, in a successful regimen the viral load should decline by at least 1 log by 4 weeks after treatment initiation; slower rates should prompt closer assessment of patient adherence, viral resistance, and possible drug-drug interactions.
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