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Can histoplasmosis come back? Histoplasmosis is caused by the reproductive cells (spores) of the fungus Histoplasma capsulatum. Even if you've had histoplasmosis in the past, you can still get the infection again. However, if you contract histoplasmosis again, the illness will likely be milder than the initial infection.
What organs does histoplasmosis affect? Severe histoplasmosis Called disseminated histoplasmosis, this variety can affect nearly any part of your body, including your mouth, liver, central nervous system, skin and adrenal glands. If untreated, disseminated histoplasmosis is usually fatal.
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