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Therapeutic treatment with clozapine in people with malfunctions of the hippocampus such as seen in schizophrenia may improve cognitive performance, whereas the same doses of clozapine may impair memory in individuals without hippocampal malfunction.

Drug-induced psychosis in patients with Parkinson's disease is a difficult problem to manage.

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Clozapine is supplied to the patient in quantities sufficient to continue treatment only until the next required blood test and only if the previous blood tests have been performed and the results are within an acceptable range.

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After initial therapeutic response occurs, the dose should be progressively reduced to the minimum level necessary to maintain clinical remission.

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