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For Urinary Tract Infection: "I immediately got worried because of the many negative reviews for this drug.

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Approximately 44% of trimethoprim and 70% of sulfamethoxazole are bound to plasma proteins.

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In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.

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Since sulfamethoxazole is often prescribed in combination with trimethoprim (for example, in Bactrim or Septra), it may be easy to associate this interaction with trimethoprim.

Trimethoprim-sulfamethoxazole in the treatment of bacteriuria in women.

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Generally, the medication is considered safe during pregnancy, except with rare genetic metabolic deficiencies.

Gastrointestinal: Hepatitis (including cholestatic jaundice and hepatic necrosis), elevation of serum transaminase and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.

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In a randomised controlled trial including 252 patients with severe MRSA infections, trimethoprim-sulfamethoxazole did not fulfil criteria for non-inferiority to vancomycin.

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However, after normalizing by body weight, the apparent total body clearance of trimethoprim was an average 19% lower in geriatric subjects compared with young adult subjects.

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Standardized procedures are based on a dilution method 3 (broth or agar) or equivalent with standardized inoculum concentrations and standardized concentrations of sulfamethoxazole and trimethoprim powder.

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The total number of people enrolled on this study is expected to be 550, and 20 at Columbia University Medical Center.

Adults: The usual adult dosage in the treatment of urinary tract infections is one SEPTRA DS (double strength) tablet, two SEPTRA tablets, or four teaspoonfuls (20 mL) SEPTRA Suspension every 12 hours for 10 to 14 days.

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Antibiotics used by general practitioners frequently appear in adverse-event reports of drug-induced hepatotoxicity.

The most common antibiotics used for treatment include trimethoprim, sulfamethocazole, amoxicillin, and ampicillin.

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Additional side effects associated with the oral form of sulfamethoxazole and trimethoprim are shortness of breath, changes in skin color, vomiting of blood, joint or muscle pain, loss of appetite, nausea, rash and wheezing, according to the Mayo Clinic.

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