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How is isotretinoin prescribed? Accutane (isotretinoin) should be administered with a meal (see PATIENT INFORMATION). The recommended dosage range for Accutane (isotretinoin) is 0.5 to 1.0 mg/kg/day given in two divided doses with food for 15 to 20 weeks. Failure to take Accutane (isotretinoin) with food will significantly decrease absorption.
Does Accutane cause extreme fatigue? High doses of vitamin A can cause headache, depression, fatigue, irritability, aggression, even personality change and psychosis — a syndrome called hypervitaminosis A. So it's no surprise that there are concerns about Accutane side effects.
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