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Efavirenz: Assessment of adverse reactions is based on three pediatric clinical trials in 182 HIV-1 infected pediatric subjects 3 months to 21 years of age, who received efavirenz in combination with other antiretroviral agents for a median of 123 weeks.

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Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from VFEND, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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Additive effects occur when the use of two drugs leads to enhanced pharmacologic activity.

Proven or suspected acute hepatitis within 30 days prior to study entry (this excludes liver inflammation related to acute HIV infection).

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Do not take two doses at the same time to make up for a missed dose.

Because of the risk for development of skin or hypersensitivity reactions and neuropsychiatric disorders, the has recommended that new patient prescriptions should only be to treat sleepiness associated with narcolepsy.

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Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial.

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Unless otherwise noted, frequency of adverse events is as reported in adults receiving combination antiretroviral therapy.

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However, in patients with primarily extrapulmonary involvement or disseminated disease, the CD4 cell count may be much lower.

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En 2006, la FDA aprobó la combinación de tenofovir, emtricitabina y efavirenz en una misma tableta, lo que facilita la adherencia de los pacientes al tratamiento antirretroviral.

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This procedure will provide potentially important information on genetic influences on plasma drug concentrations and give insight into how to improve the management of HIV-infected patients by individualising therapy.

Patients who take ergot alkaloids, midazolam, astemizole, cisapride or triazolam should avoid Efavir.

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Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks.

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If a relapse of depression occurs after HAART initiation, a change in antiretroviral treatment may be necessary.

As a rule of thumb, in a successful regimen the viral load should decline by at least 1 log by 4 weeks after treatment initiation; slower rates should prompt closer assessment of patient adherence, viral resistance, and possible drug-drug interactions.

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Clarke S, Harrington P, Barry M, Mulcahy F "The tolerability of efavirenz after nevirapine-related adverse events.

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